A16 Population genetics of hematopoietic neoplasms
The development of a tumor can be considered as an evolutionary process. From this point of view, e.g. chemotherapy generates an evolutionary pressure, and the gain of resistance can be understood as evolutionary adaptation in the tumor. We develop theoretical tools to analyze these evolutionary processes in hematopoietic neoplasms, including the role of genetic and epigenetic mutation. For this we adopt approaches of stochastic modeling and of data analysis from evolutionary biology and in particular from population genetics.
Figure legend: Simulation strategy by which the dynamics of the clones is simulated forward in time. Given the result of this step, the genealogies of sampled cells are then simulated backward in time as a process of coalescing ancestral lineages.