SFB 1243 Cancer Evolution
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SFB 1243 Publications

2018

Wenk C, Garz AK, Grath S, Huberle C, Witham D, Weickert M, Malinverni R, Niggemeyer J, Kyncl M, Hecker J, Pagel C, Mulholland CB, Müller-Thomas C, Leonhardt H, Bassermann F, Oostendorp RAJ, Metzeler KH, Buschbeck M and Götze KS. Direct modulation of the bone marrow mesenchymal stromal cell compartment by azacitidine enhances healthy hematopoiesis. Blood Adv. (Nov 2018) 2, 3447-3461. doi: https://doi.org/10.1182/bloodadvances.2018022053.

Hellmuth JC, Louissant A, Szczepanowski M, Haebe S, Pastore A, Alig S, Staiger AM, Hartmann S, Kridel R, Ducar MD, Koch P, Dreyling M, Hansmann M-L, Ott G, Rosenwald A, Gascoyne RD, Weinstock DM, Hiddemann W, Klapper W, Weigert ODuodenal type and nodal follicular lympohoma differ by their immune microenvironment rahter than their mutation profiles. Blood. Aug 2018. pii: blood-2018-03-837252. doi: 10.1182/blood-2018-03-837252. [Epub ahead of print].

Rothenberg-Thurley M, Amler S, Goerlich D, Köhnke T, Konstandin NP, Schneider S, Sauerland MC, Herold T, Hubmann M, Ksienzyk B, Zellmeier E, Bohlander SK, Subklewe M, Faldum A, Hiddemann W, Braess J, Spiekermann K, Metzeler KH. Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia. Leukemia. 2018 Jul;32(7):1598-1608. doi: 10.1038/s41375-018-0034-z.

Stosch JM, Heumüller A, Niemöller C, Bleul S, Rothenberg-Thurley M, Riba J, Renz N, Szarc Vel Szic K, Pfeifer D, Follo M, Pahl HL, Zimmermann S, Duyster J, Wehrle J, Lübbert M, Metzeler KH, Claus R, Becker H. Gene mutations and clonal architecture in myelodysplastic syndromes and changes upon progression to acute myeloid leukaemia and under treatment. Br J Haematol. 2018 Jul 5. doi: 10.1111/bjh.15461.

Schranz K, Hubmann M, Harin E, Vosberg S, Herold T, Metzeler KH, Rothenberg-Thurley M, Janke H, Bräundl K, Ksienzyk B, Batcha AMN, Schaaf S, Schneider S, Bohlander SK, Görlich D, Berdel WE, Wörmann BJ, Braess J, Krebs S, Hiddemann W, Mansmann U, Spiekermann K, Greif PA. Clonal heterogeneity of FLT3-ITD detected by high-throughput amplicon sequencing correlates with adverse prognosis in acute myeloid leukemia. Oncotarget. 2018 Jul 10;9(53):30128-30145. doi: 10.18632/oncotarget.25729.

Vosberg S, Hartmann L, Metzeler KH, Konstandin NP, Schneider S, Varadharajan A, Hauser A, Krebs S, Blum H, Bohlander SK, Hiddemann W, Tischer J, Spiekermann K, Greif PA. Relapse of acute myeloid leukemia after allogeneic stem cell transplantation is associated with gain of WT1 alterations and high mutation load. Haematologica. 2018 Jun 28. pii: haematol.2018.193102. doi:10.3324/haematol.2018.193102.

Prassek VV, Rothenberg-Thurley M, Sauerland MC, Herold T, Janke H, Ksienzyk B, Konstandin NP, Goerlich D, Krug U, Faldum A, Berdel WE, Wörmann B, Braess J, Schneider S, Subklewe M, Bohlander SK, Hiddemann W, Spiekermann K, Metzeler KH. Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged ≥ 75 years. Haematologica. 2018 Jun 14. pii: haematol.2018.191536. doi: 10.3324/haematol.2018.191536.

Link V, Duttke S, Chun H, Holtman I, Westin E, Hoeksema M, Abe Y, Skola, D, Romanoski C, Tao J, Fonseca G, Troutman T, Spann N, Strid T, Sakai M, Yu M, Hu R, Fang F, Metzler D, Ren B, Glass C.  Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and
Function. Cell (2018) 173:1–14. DOI: https://doi.org/10.1016/j.cell.2018.04.018

Parekh S, Ziegenhain C, Vieth B, Enard W, Hellmann I. zUMIs - A Fast and Flexible Pipeline to Process RNA Sequencing Data with UMIs. GigaScience 2018 7 (6). https://doi.org/10.1093/gigascience/giy059.

Bagnoli JW, Ziegenhain C, Janjic A, Wange LE, Vieth B, Parekh S, Geuder J, Hellmann I, Enard W Sensitive and powerful single-cell RNA sequencing using mcSCRB-seq.   Nature Communications (2018) 9: 2937. DOI: 10.1038/s41467-018-05347-6

Reidel V, Kauschinger J, Hauch RT, Müller-Thomas C, Nadarajah N, Burgkart R, Schmidt B, Hempel D, Jacob A, Slotta-Huspenina J, Höckendorf U, Peschel C, Kern W, Haferlach T, Götze KS, Jilg S, Jost PJ. Selective inhibition of BCL-2 is a promising target in patients with high-risk myelodysplastic syndromes and adverse mutational profile. Oncotarget (2018) Apr. 3; 9 (25): 17270-17281. doi:10.18632/oncotarget.24775.

Bultmann S, Stricker SH Entering the post-epigenomic age: back to epigenetics Open Biology (2018 Mar 28) 8: 180013. DOI: 10.1098/rsob.180013

Jurinovic V, Metzner B, Pfreundschuh M, Schmitz N,  Wandt H, Keller U, Dreger P, Dreyling M, Hiddemann W, Unterhalt M, Hoster E*, Weigert O*  Autologous Stem Cell Transplantation for Patients with Early Progression of Follicular Lymphoma: A Follow-up Study of Two Randomized Trials from the German Low Grade Lymphoma Study Group. Biol Blood Marrow Transplant (2018, accepted on March 23) Jun; 24(6):1172-1179. doi: 10.1016/j.bbmt.2018.03.022.

Ziegenhain C, Vieth B, Parekh S, Hellmann I and Enard W  Quantitative single-cell transcriptomics. Briefings in Functional Genomics (2018) 1-13. doi: 10.1093/bfgp/ely009.

Alig S, Jurinovic V, Pastore A, Bararia D, Häbe S, Hellmuth JC, Kridel R, Gascoyne R, Schmidt C, Zöllner A, Buske C, Dreyling M, Unterhalt M, Hiddemann W, Hoster E, Weigert O  Impact of age on genetics and treatment efficacy in follicular lymphoma. Haematologica. (2018) Epub ahead of print, doi: 10.3324/haematol.2018.187773

Fung E, Richter C, Yang HB, Schäffer I, Fischer R, Kessler BM, Bassermann F*, D'Angiolella V*  FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration. EMBO Rep. (2018) 19, pii: e44799. doi: 10.15252/embr.201744799. *equal contribution/last authorship

Herold T, Jurinovic V, Batcha AMN, Bamopoulos SA, Rothenberg-Thurley M, Ksienzyk B, Harmann L, Greif PA, Phillippou-Massier J, Krebs S, Blum H, Amler S, Schneider S, Konstandin N, Sauerland MC, Görlich D, Berdel WE, Wörmann BJ, Tischer J, Subklewe M, Bohlander SK, Braess J, Hiddemann W, Metzeler KH, Mansmann U, Spiekermann K  A 29-gene and cytogenetic score for the prediction of resistance to indcution treatment in acute myeloid leukemia. Haematologica (2018 Mar) 103:456-465. doi: 10.3324/haematol.2017.178442

Cusan M, Cai SF, Mohammad HP, Krivtsov A, Chramiec A, Loizou E, Witkin MD, Smitheman KN, Tenen DG, Ye M, Will B, Steidl U, Kruger RG, Levine RL, Rienhoff Jr. HY, Koche RP, Amrstrong SA LSD1 inhibition exerts its anti-leukemic effect by recommissioning PU.1- and C/EBPa-dependent enhancers in AML. Blood 2018 :blood-2017-09-807024; doi: https://doi.org/10.1182/blood-2017-09-807024

Reiter K, Polzer H, Krupka C, Maiser A, Vick B, Rothenberg-Thurley M, Metzeler KH, Dörfel D, Salih HR, Jung G, Nößner E, Jeremias I, Hiddemann W, Leonhardt H, Spiekermann K, Subklewe M, Greif PA. Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia. Leukemia (2018 Feb) 32(2):313-322. doi: 10.1038/leu.2017.257.

Greif PA, Hartmann L, Vosberg S, Stief SM, Mattes R, Hellmann I, Metzeler KH, Herold T, Bamopoulos SA, Kerbs P, Jurinovic V, Schumacher D, Pastore F, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Graf A, Krebs S, Blum H, Neumann M, Baldus CD, Bohlander SK, Wolf S, Görlich D, Berdel WE, Wörmann BJ, Hiddemann W, Spiekermann K Evolution of cytogenetically normal Acute Myeloid Leukemia during therapy and relapse: An exome sequencing study of 50 patients. Clinical Cancer Research (2018) 1-11. DOI: 10.1158/1078-0432.CCR-17-2344. http://clincancerres.aacrjournals.org/content/early/2018/02/25/1078-0432.CCR-17-2344

Mueller S, Engleitner T, Maresch R, Zukowska M, Lange S, Kaltenbacher T, Konukiewitz B, Öllinger R, Zwiebel M, Strong A, Yen HY, Banerjee R, Louzada S, Fu B, Seidler B, Götzfried J, Schuck K, Hassan Z, Arbeiter A, Schönhuber N, Klein S, Veltkamp C, Friedrich M, Rad L, Barenboim M, Ziegenhain C, Hess J, Dovey OM, Eser S, Parekh S, Constantino-Casas F, de la Rosa J, Sierra MI, Fraga M, Mayerle J, Klöppel G, Caninaños J, Liu P, Vassiliou G, Weichert W, Steiger K, Enard W, Schmid RM, Yang F, Unger K, Schneider G, Varela I, Bradley A, Saur D, Rad R  Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes. Nature (2018) 554:62-68. doi:10.1038/nature25459. https://www.nature.com/articles/nature25459

Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V Binding of NUFIP2 to Rophin promotes recognition and regulation of ICOS mRNA. Nature Communications (2018) 9:299. DOI: 10.1038/s41467-017-02582-1.

Habringer S, Lapa C, Herhaus P, Schottelius M, Istvanffy R, Steiger K, Slotta-Huspenina J, Schirbel A, Hänscheid H, Kircher S, Buck AK, Götze K, Vick B, Jeremias I, Schwaiger M, Peschel C, Oostendorp R, Wester HJ, Grigoleit GU, Keller U. Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4 Directed Theranostics. Theranostics (2018) Jan 1; 8(2): 369-383. doi: 10.7150/thno.21397.

2017

Essig K, Hu D, Guimaraes JC, Alterauge D, Edelmann S, Raj T, Kranich J, Behrens G, Helseke A, Floess S, Klein J, Maiser A, Marschall S, Hrabe de Angelis M, Leonhardt H, Calkhoven CF, Noessner E, Brocker T, Huehn J, Krug AB,  Zavolan M, Baumjohann D, Heissmeyer V Roquin suppresses the PI3K-mTOR Signaling Pathway to inhibit T helper cell differentiation and conversion of Treg to Tfr cellsImmunity 47, 1067-1082 (2017 Dec 19) https://doi.org/10.1016/j.immuni.2017.11.008

Palau A, Garz AK, Diesch J, Zwick A, Malinverni R, Valero V, Lappin K, Casquero R, Lennartsson A, Zuber J, Navarro T, Mills KI, Götze KS, Buschbeck M Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes. Oncotarget (2017 Dec 1) 8(70):115002-115017. doi: 10.18632/oncotarget.22839

Klaeger S, Heinzlmeir A, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tõnisson N, Kramer K, Götze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Médard G, Jeremias I, Spiekermann K, Kuster B The target landscape of clinical kinase drugs. Science (2017 Dec 01) 358:6367. doi: 10.1126/science.aan4368

Mottok A, Jurinovic V, Farinha P, Rosenwald A, Leich E, Ott G, Horn H, Klapper W, Boesl M, Hiddemann W, Steidl C, Connors JM, Sehn LH, Gascoyne RD, Hoster E, Weigert O, Kridel R FOXP1 expression is a prognostic biomarker in follicular lymphoma treated with Rituximab-containing regimens. Blood (2017, accepted Oct 27) Jan 11; 131(2):226-235. doi: 10.1182/blood-2017-08-799080.

Garz AK, Wolf S, Grath S, Gaidzik V, Habringer S, Vick B, Rudelius M, Ziegenhain C, Herold S, Weickert M, Smets M, Peschel C, Oostendorp R, Bultmann S, Jeremias I, Thiede C, Döhner K, Keller U, Götze KS. Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in FLT3-ITD AML with concurrent epigenetic mutations. Oncotarget (2017 Oct 16). Online ISSN: 1949-2553. doi.org/10.18632/oncotarget.21877

Weigert O, Weinstock DM The promises and challenes of using gene mutations for patient stratification in follicular lympohma. Blood (2017 Sept 28) 130(13): 1491-1498. doi: 10.1182/blood-2017-07-737353.

Vieth B, Ziegenhain C, Parekh S, Enard W, Hellmann I. powsimR: Power analysis for bulk and single cell RNA-seq experiments. Bioinformatics (2017). https://doi.org/10.1093/bioinformatics/btx435

Krautenbacher N, Theis F, Fuchs C Correcting classifiers for sample selection bias in two-phase case-control studies. Computational and Mathematical Methods in Medicine (2017) Article ID 7847531. DOI:10.1155/2017/7847531

Schlenker R, Olguín-Contreras LF, Leisegang M, Schnappinger J, Disovic A, Rühland S, Nelson PJ, Leonhardt H, Harz H, Wilde S, Schendel DJ, Uckert W, Willimsky G, Noessner E. Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy. Cancer Research (2017) 11(13): 3577-3590. DOI: 10.1158/0008-5472.CAN-16-1922

Ziegenhain C, Vieth B, Parekh S, Reinius B, Guillaumet-Adkins A, Smets M, Leonhardt H, Heyn H, Hellmann I, Enard W.  Comparative Analysis of Single-Cell RNA Sequencing Methods. Molecular Cell (2017) 65(4): 631-643. DOI:https://doi.org/10.1016/j.molcel.2017.01.023

Seyednasrollah F, Koestler D, Wang T, Piccolo S, Vega R, Greiner R, Fuchs C, ..., Costello J, Prostate Cancer DREAM Challenge Community A DREAM challenge to build prediction models for short-term discontinuation of docetaxel in metastatic castration-resistant prostate cancer. Journal of Clinical Oncology Clinical Cancer Informatics(Nov 2017). DOI: 10.1200/CCI.17.00018 JCO Clinical Cancer Informatics - published online August 4, 2017

Guinney J, Wang T, Laajala T, Fuchs C, ..., Costello J, Prostate Cancer Challenge DREAM Community Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data. The Lancet Oncology (2017):18, 132-142. DOI: 10.1016/S1470-2045(16)30560-5

Jacobsen C, Kopp N, Layer JV, Redd RA, Tschuri S, Haebe S, van BodegomD, Bird L, Christie AL, Christodoulou A, Saur A, Tivey T, Zapf S, Deepak B, Zimber-Strobl U, Rodig SJ, Weigert O, Weinstock DM.  HSP90 inhibition overcomes ibrutinib resistance in mantel cell lymphoma. Blood (2017) 128 (21): 2517-2526. DOI 10.1182/blood-2016-04-711176

de la Rosa J, Weber J, Friedrich MJ, Li Y, Rad L, Ponstingl H, Liang Q, Bernaldo de Quirós S, Noorani I, Metzakopian E, Strong A, Li MA, Astudillo A, Fernández-García MT, Fernández-García MS, Hoffman GJ, Fuente R, Vassiliou GS, Rad R, López-Otín C, Bradley A, Cadiñanos J. A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes. Nature Genetics (2017) 49(5): 730-743. doi:10.1038/ng.3817

Buggenthin F, Buettner F, Hoppe PS, Endele M, Kroiss, M, Strasser, M, Schwarzfischer M, Loeffler D, Kookaliaris KD, Hilsenbeck O, Schroeder T, Theis FJ, Marr C. Prospective identification of hematopoietic lineage choice by deep learning. Nature Methods (2017) 14: 403-406. doi:10.1038/nmeth.4182

Kronke J, Kuchenbauer F, Kull M, Teleanu V, Bullinger L, Bunjes D, Greiner A, Kolmus S, Kopff S, Schreder M, Mügge LO, Straka C, Engelhardt M, Döhner H, Einsele H, Bassermann F, Bargou R, Knop S, Langer C  IKZF1 expression is a prognostic marker in newly diagnosed standard-risk multiple myeloma treated with lenalidomide and intensive chemotherapy: a study of the German Myeloma Study Group (DSMM). Leukemia (2017) 31, 1363-1367. doi:10.1038/leu.2016.384

Friedrich MJ, Rad L, Bronner IF, Strong A, Wang W, Weber J, Mayho M, Ponstingl H, Engleitner T, Grove C, Pfaus A, Saur D, Cadiñanos J, Quail MA, Vassiliou GS, Liu P, Bradley A, Rad R. Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice. Nature Protocols (2017) 12(2):289-309. doi:10.1038/nprot.2016.164

Ponce LP, Fenn NC, Mortiz N, Krupka C, Kozik JH, Lauber K, Sublewe M, Hopfner KP. SIRPα-antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells. Oncotarget, Advance Publications (2017) 8: 1124-11301. https://doi.org/10.18632/oncotarget.14500

Schreck C, Istvánffy R, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian MC, Mende N, Taubenberger A, Prendergast Á, Wagner A, Pagel C, Grziwok S, Götze KS, Guck J, Dean DC, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp RAJ. Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells. J Exp Med (2017) Jan;214(1):165-181. doi: 10.1084/jem.20151414.

2016

Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, Görlich D, Büchner T, Hiddemann W, Berdel WE, Wörmann B, Cheok M, Preudhomme C, Dombret H, Metzeler K, Buske C, Löwenberg B, Valk PJ, Zandstra PW, Minden MD, Dick JE, Wang JC. A 17-gene stemness score for rapid determination of risk in acute leukaemia. Nature. (2016)  Dec 15;540(7633):433-437. doi: 10.1038/nature20598. Epub 2016 Dec 7.

Riba J, Renz N, Niemöller C, Bleul S, Pfeifer D, Stosch JM, Metzeler KH, Hackanson B, Lübbert M, Duyster J, Koltay P, Zengerle R, Claus R, Zimmermann S, Becker H. Molecular Genetic Characterization of Individual Cancer Cells Isolated via Single-Cell Printing. PLoS One. (2016) Sep 22;11(9):e0163455. doi: 10.1371/journal.pone.0163455.

Diesch J, Zwick A, Garz AK, Palau A, Buschbeck, Götze K A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers. Clinical Epigenetics (2016) Jun 21; 8:71. doi: 10.1186/s13148-016-0237-y

Engel K, Rudelius M, Slawska J, Ahangarian Abhari B, Altmann B, Kurutz J, Brunner A, Targosz BS, Loewecke F, Knorn AM, Gloeckner CJ, Ueffing M, Fernandez-Sáiz V, Baumann U, Fulda S, Pfreundschuh M, Trümper L, Klapper W, Keller U, Jost PJ, Rosenwald A, Peschel C, Bassermann F  USP9X stabilizes XIAP to regulate mitotic cell death and mediate resistance to anti-tubulin chemotherapeutics in aggressive B-cell lymphoma. EMBO Mol. Med. (2016) 8, 851-62. DOI 10.15252/emmm.201506047

Eichner R, Heider M, Fernández-Sáiz V, van Bebber F, Garz AK, Lemeer S, Rudelius M, Targosz BS, Jacobs L, Knorn AM, Slawska J, Platzbecker U, Germing U, Langer C, Knop S, Einsele H, Peschel C, Haass C, Keller U, Schmid B, Götze KS, Kuster B, and Bassermann F Immunomodulatory drugs disrupt the CRBN-CD147/MCT1 axis to exert anti-tumor activity and teratogenicity. Nature Medicine (2016) 22, 735-743. doi:10.1038/nm.4128

Ebinger S, Özdemir EZ, Ziegenhain C, Tiedt S, Castro Alves C, Grunert M, Dworzak M, Lutz C, Turati VA, Enver T, Horny HP, Sotlar K, Parekh S, Spiekermann K, Hiddemann W, Schepers A, Polzer B, Kirsch S, Hoffmann M, Knapp B, Hasenauer J, Pfeifer H, Panzer-Grümayer R, Enard W, Gires O, Jeremias I. Characterization of Rare, Dormant and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia. Cancer Cell (2016) 30: 849-862. DOI:https://doi.org/10.1016/j.ccell.2016.11.002

Kondofersky I, Laimighofer M, Kurz C, Krautenbacher N, Söllner J, Dargatz P, Scherb H, Ankerst D, Fuchs C Three general concepts to improve risk prediction: good data, wisdom of the crowd, recalibration. F1000Research (2016):5(2671). DOI: 10.12688/f1000research.8680.1.

Jurinovic v, Kridel R, Staiger AM, Szczepanowski M, Horn H, Dreyling MH, Rosenwald A, Ott G, Klapper W, Zelenetz AD, Barr PM, Friedberg JW, Ansell S, Sehn LH, Connors JM, Gascoyne RD, Hiddemann W, Unterhalt M, Wenstock DM, Weigert O. Clinicogenetic risk models predict early progression of follicular lymphoma after first-line immunochemotherapy. Blood (2016) 128(8): 1112-1120. doi:10.1182/blood-2016-05-717355

Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Harmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K, on behalf of the AMLCG Study Group. Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia. Blood (2016) 128(5): 686-698. DOI 10.1182/blood-2016-01- 693879

Parekh S, Ziegenhain C, Vieth B, Enard W, Hellmann I. The impact of amplification on differential expression analyses by RNA-seq. Nature Scientific Reports (2016) 6:25533. DOI: 10.1038/srep25533

Kondofersky I, Theis F, Fuchs C Inferring catalysis in biological systems. IET Systems Biology (2016):10(6)210-218. DOI: 10.1049/iet-syb.2015.0087.

Melchardt T, Hufnagl C, Weinstock DM, Kopp N, Neureiter D, Tränkenschuh W, Hackl H, Weiss L, Rinnerthaler G, Hartmann TN, Greil R, Weigert O, Egle A. Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones. Oncotarget, Advanced Publications.  (2016) 7: 51494-51502. https://doi.org/10.18632/oncotarget.9860

Hartmann L, Dutta S, Opatz S, Vosberg S, Reiter K, Leubolt G, Metzeler KH, Herold, T, Bamopoulos SA, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Hopfner KP, Graf A, Krebs S, Blum H, Middeke JM, Stölzel F, Thiede C, Wolf S, Bohlander SK, Preiss C, Chen-Wichmann L, Wichmann C, Sauerland MC, Büchner T, Berdel WE, Wörmann BJ, Braess J, Hiddemann W, Spiekermann K, Greif PA. ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation. Nature Communications (2016) 7:11733. doi: 10.1038/ncomms11733.