SFB 1243 Cancer Evolution
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Final Program

Thursday, March 1

Audimax, Biomedical Center Munich, Grosshaderner Str. 9, 82152 Planegg-Martinsried

  • 15:00 - 16:00  Registration in the Audimax foyer
  • 16:00 - 16:10  Welcome (Heinrich Leonhardt), Open Keynote lectures in the Audimax of the BMC
    The keynote lectures are open to all in the campus community!

16:10 - 16:20      Introduction (Wolfgang Enard)
16:20 - 17:15     LIRAN SHLUSH, Weizmann Institute of Science, Rehovot, Israel
                           Early evolution of AML

17:15 - 17:25      Introduction (Oliver Weigert)
17:25 - 18:20     CATHERINE J. WU, Dana-Farber Cancer Institute, Boston, USA
                           Chronic lymphocytic leukemia is a disease model to study clonal evolution

Friday, March 2

Large Lecture Hall, Biocenter, Grosshaderner Str. 2, 82152 Planegg-Martinsried

  • 8:00 - 9:00      Registration in the Biocenter foyer
  • Session 1 Evolution during tumorigenesis (Katharina Götze)
    09:00 - 09:30   Bertrand NADEL, Marseille, France
                            Early steps of follicular lymphoma development
    09:30 - 10:00   Roland RAD, Munich, Germany
                            Evolutionary routes and KRAS dosage define cancer phentoypes
    10:00 - 10:30   Constanze BONIFER, Birmingham, UK
                            Subtype-specific global regulatory network rewiring in Acute Myeloid Leukemia

     10:30 - 11:00   Break

  • Session 2 Clinical Translation in Leukemia and Lymphoma (Florian Bassermann)
    11:00 - 11:30   Lars BULLINGER, Berlin, Germany
                            Precision Medicine in Acute Myeloid Leukemia – Fact or Fiction?
    11:30 - 11:45   Monica Cusan, Munich, Germany
                            LSD1 inhibition exerts its anti-leukemic effect by recommissioning PU.1- and C/EBPα-
                            dependent enhancers in AML

    11:45 - 12:00   Wen-Hsin Liu, Munich, Germany
                            Re-expression of KLF4 impairs growth of patient-derived acute lymphoma leukemia cells in vivo and
                            sensitizes towards chemotherapy

    12:00 - 12:30   Claudia BALDUS, Berlin, Germany
                            Clonal evolution in relapsed B-cell precursor acute lymphoblastic leukemia

     12:30 - 13:30   Lunch
     13:30 - 15:00   Poster Session

  • Session 3 Computational modeling of tumor evolution (Fabian J. Theis)
    15:00 - 15:30   Fabian J. THEIS, Munich, Germany
                            Lineage estimation from single-cell RNAseq time-series
    15:30 - 15:45   Merja Heinäniemi, Kuopio, Finland
                            Genome-wide analysis of the regulatory landscape in different pre-B-ALL subtypes
    15:45 - 16:00   Verena Körber, Heidelberg, Germany
                            Clonal evolution in adult glioblastoma
    16:00 - 16:30   Carsten Marr, Munich, Germany
                            Computational models of hematopoietic neoplasms

     16:30 - 17:00   Break

  • Session 4 Experimental modeling of tumor evolution (Irmela Jeremias)
    17:00 - 17:30   Sandrine SANDER, Heidelberg, Germany
                            Tumor evolution in Burkitt lymphomagenesis
    17:30 - 17:45   Cyrus Khandanpour, Essen, Germany
                            Alteration of the transcription factor GFI1 as a driver of genetic instability of leukemia development
    17:45 - 18:15   Ralf KÜPPERS, Essen, Germany
                            Genetic and infectious mechanisms of B-cell lymphoma pathogenesis
    18:15 - 18:45   Rebekka K. SCHNEIDER, Rotterdam, The Netherlands
                            Dissecting the fibrotic transformation in myeloproliferative neoplasms

     18:45 - 20:00  Poster Session and Happy Hour

     20:00 -            Dinner and Get-together for all participants

Saturday, March 3

  • Session 5 Genomic technologies to study tumor evolution (Wolfgang Enard)
    09:00 - 09:30   Thierry VOET, Leuven, Belgium
                            Single-cell multi-omics to study the biology of cellular heterogeneity in health and disease
    09:30 - 09:45   Johannes Bagnoli, Munich, Germany
                            mcSCRB-seq: Sensitive and powerful single-cell RNA sequencing
    09:45 - 10:00   Beate Vieth, Munich, Germany
                            
    powsimR: Statistical power analysis for bulk and single cell RNA-seq experiments
    10:00 - 10:15   Christian Matek, Munich, Germany
                            Recognising and classifying cell populations characteristic of Acute Myeloid Leukemia in digitized
                            blood smears

    10:15 - 10:30   Stefan Krebs, Munich, Germany
                            Nanopore sequencing provides new tools for analysis of haematological malignancies

     10:30 - 11:00   Break

  • Session 6 Evolution during antitumor treatment (Klaus Metzeler)
    11:00 - 11:30   Ruud DELWEL, Rotterdam, The Netherlands
                            Enhancer defects in acute myeloid leukemia
    11:30 - 11:45   Lucia Zanotti, Milan, Italy
                            Genomic and Transcriptional Profiling of Acute Myeloid Leukemia by Next-Generation Sequencing
                            Unravels Patient-Specific Patterns of Post-Transplantation Relapse

    11:45 - 12:00   Bettina Lindl, Munich, Germany
                            Midostaurin Reduces CD135xCD3 Antibody Mediated Cytotoxicity Against AML
    12:00 - 12:30   Liran SHLUSH, Rehovot, Israel
                            Understanding AML Relapse Biology

    12:30               Poster competition awards: Congratulations to Seren Baygun, Carmen Richter and Jan-Hendrik Kozik!
                           Closing remarks (Heinrich Leonhardt)