Final Program

Thursday, March 1

Audimax, Biomedical Center Munich, Grosshaderner Str. 9, 82152 Planegg-Martinsried

• 15:00 - 16:00  Registration in the Audimax foyer
• 16:00 - 16:10  Welcome (Heinrich Leonhardt), Open Keynote lectures in the Audimax of the BMC
  The keynote lectures are open to all in the campus community!
  

16:10 - 16:20      Introduction (Wolfgang Enard)
16:20 - 17:15     LIRAN SHLUSH, Weizmann Institute of Science, Rehovot, Israel
                           Early evolution of AML

17:15 - 17:25      Introduction (Oliver Weigert)
17:25 - 18:20     CATHERINE J. WU, Dana-Farber Cancer Institute, Boston, USA
                           Chronic lymphocytic leukemia is a disease model to study clonal evolution

Friday, March 2

Large Lecture Hall, Biocenter, Grosshaderner Str. 2, 82152 Planegg-Martinsried

• 8:00 - 9:00      Registration in the Biocenter foyer
• Session 1 Evolution during tumorigenesis (Katharina Götze)
  09:00 - 09:30   Bertrand NADEL, Marseille, France
                          Early steps of follicular lymphoma development
  09:30 - 10:00   Roland RAD, Munich, Germany
                          Evolutionary routes and KRAS dosage define cancer phentoypes
  10:00 - 10:30   Constanze BONIFER, Birmingham, UK
                          Subtype-specific global regulatory network rewiring in Acute Myeloid Leukemia

     10:30 - 11:00   Break

• Session 2 Clinical Translation in Leukemia and Lymphoma (Florian Bassermann)
  11:00 - 11:30   Lars BULLINGER, Berlin, Germany
                          Precision Medicine in Acute Myeloid Leukemia – Fact or Fiction?
  11:30 - 11:45   Monica Cusan, Munich, Germany
                          LSD1 inhibition exerts its anti-leukemic effect by recommissioning PU.1- and C/EBPα-
                          dependent enhancers in AML
  11:45 - 12:00   Wen-Hsin Liu, Munich, Germany
                          Re-expression of KLF4 impairs growth of patient-derived acute lymphoma leukemia cells in vivo and
                          sensitizes towards chemotherapy
  12:00 - 12:30   Claudia BALDUS, Berlin, Germany
                          Clonal evolution in relapsed B-cell precursor acute lymphoblastic leukemia

     12:30 - 13:30   Lunch
     13:30 - 15:00   Poster Session

• Session 3 Computational modeling of tumor evolution (Fabian J. Theis)
  15:00 - 15:30   Fabian J. THEIS, Munich, Germany
                          Lineage estimation from single-cell RNAseq time-series
  15:30 - 15:45   Merja Heinäniemi, Kuopio, Finland
                          Genome-wide analysis of the regulatory landscape in different pre-B-ALL subtypes
  15:45 - 16:00   Verena Körber, Heidelberg, Germany
                          Clonal evolution in adult glioblastoma
  16:00 - 16:30   Carsten Marr, Munich, Germany
                          Computational models of hematopoietic neoplasms
  

     16:30 - 17:00   Break

• Session 4 Experimental modeling of tumor evolution (Irmela Jeremias)
  17:00 - 17:30   Sandrine SANDER, Heidelberg, Germany
                          Tumor evolution in Burkitt lymphomagenesis
  17:30 - 17:45   Cyrus Khandanpour, Essen, Germany
                          Alteration of the transcription factor GFI1 as a driver of genetic instability of leukemia development
  17:45 - 18:15   Ralf KÜPPERS, Essen, Germany
                          Genetic and infectious mechanisms of B-cell lymphoma pathogenesis
  18:15 - 18:45   Rebekka K. SCHNEIDER, Rotterdam, The Netherlands
                          Dissecting the fibrotic transformation in myeloproliferative neoplasms
  

     18:45 - 20:00  Poster Session and Happy Hour

     20:00 -            Dinner and Get-together for all participants

Saturday, March 3

• Session 5 Genomic technologies to study tumor evolution (Wolfgang Enard)
  09:00 - 09:30   Thierry VOET, Leuven, Belgium
                          Single-cell multi-omics to study the biology of cellular heterogeneity in health and disease
  09:30 - 09:45   Johannes Bagnoli, Munich, Germany
                          mcSCRB-seq: Sensitive and powerful single-cell RNA sequencing
  09:45 - 10:00   Beate Vieth, Munich, Germany
                           powsimR: Statistical power analysis for bulk and single cell RNA-seq experiments
  10:00 - 10:15   Christian Matek, Munich, Germany
                          Recognising and classifying cell populations characteristic of Acute Myeloid Leukemia in digitized
                          blood smears
  10:15 - 10:30   Stefan Krebs, Munich, Germany
                          Nanopore sequencing provides new tools for analysis of haematological malignancies

     10:30 - 11:00   Break

• Session 6 Evolution during antitumor treatment (Klaus Metzeler)
  11:00 - 11:30   Ruud DELWEL, Rotterdam, The Netherlands
                          Enhancer defects in acute myeloid leukemia
  11:30 - 11:45   Lucia Zanotti, Milan, Italy
                          Genomic and Transcriptional Profiling of Acute Myeloid Leukemia by Next-Generation Sequencing
                          Unravels Patient-Specific Patterns of Post-Transplantation Relapse
  11:45 - 12:00   Bettina Lindl, Munich, Germany
                          Midostaurin Reduces CD135xCD3 Antibody Mediated Cytotoxicity Against AML
  12:00 - 12:30   Liran SHLUSH, Rehovot, Israel
                          Understanding AML Relapse Biology
  
  12:30               Poster competition awards: Congratulations to Seren Baygun, Carmen Richter and Jan-Hendrik Kozik!
                         Closing remarks (Heinrich Leonhardt)