Prof. Dr. Gunnar Schotta

10 Major publications related to project

Ernst M, Abu Dawud R, Kurtz A, Schotta G, Taher L and Fuellen G (2015). Comparative computational analysis of pluripotency in human and mouse stem cells. Sci Rep., 5, 7927.

Sadic D, Schmidt K, Groh S, Kondofersky I, Ellwart J, Fuchs C, Theis FJ and Schotta G (2015). Atrx promotes heterochromatin formation at retrotransposons. EMBO Rep., 2015 May 26. [Epub ahead of print]

Bierhoff H, Dammert MA, Brocks D, Dambacher S, Schotta G and Grummt I (2014). Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing. Mol Cell, 54, 675-682.

Dambacher S, de Almeida GP and Schotta G (2013). Dynamic changes of the epigenetic landscape during cellular differentiation. Epigenomics, 5, 701-713.

Engert S, Burtscher I, Liao WP, Dulev S, Schotta G and Lickert H (2013). Wnt/beta-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse. Development, 140, 3128-3138.

Hahn M, Dambacher S, Dulev S, Kuznetsova AY, Eck S, Worz S, Sadic D, Schulte M, Mallm JP, Maiser A, Debs P, von Melchner H, Leonhardt H, Schermelleh L, Rohr K, Rippe K, Storchova Z, and Schotta G (2013). Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin. Genes Dev, 27, 859-872.

Nicetto D, Hahn M, Jung J, Schneider TD, Straub T, David R, Schotta G and Rupp RA (2013). Suv4-20h histone methyltransferases promote neuroectodermal differentiation by silencing the pluripotency-associated Oct-25 gene. PLoS Genet, 9, e1003188.

Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callen E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M and Jenuwein T (2008). A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev, 22, 2048-2061.

Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, Iyer NG, Perez-Rosado A, Calvo E, Lopez JA, Cano A, Calasanz MJ, Colomer D, Piris MA, Ahn N, Imhof A, Caldas C, Jenuwein T and Esteller M (2005). Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nature Genetics, 37, 391-400.

Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D and Jenuwein T (2004). A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev, 18, 1251-1262.