SFB 1243 Cancer Evolution

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Leonhardt, Heinrich

Prof. Dr. Heinrich Leonhardt

Faculty of Biology, Ludwig-Maximilians-Universität München


Speaker of the SFB 1243


Center for Molecular Biosystems (BioSysM)
LMU Munich
Butenandtstraße 1
81377 München

Phone: +49 (0)89 2180-74232

Website: Human Biology & BioImaging

Work group

A01 DNA modifications in the evolution of hematopoietic neoplasms

10 Major publications related to project

(See publications for recent papers published in the SFB context since 2016)

Roth S, Rottach A, Lotz-Havla AS, Laux V, Muschaweckh A, Gersting SW, Muntau AC, Hopfner KP, Jin L, Vanness K, Petrini JH, Drexler I, Leonhardt H and Ruland J (2014). Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production. Nat Immunol, 15, 538-45.

Bergink S, Ammon T, Kern M, Schermelleh L, Leonhardt H and Jentsch S (2013). Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction. Nat Cell Biol., 15, 526-32.

Solovei I, Wang AS, Thanisch K, Schmidt CS, Krebs S, Zwerger M, Cohen TV, Devys D, Foisner R, Peichl L, Herrmann H, Blum H, Engelkamp D, Stewart CL*, Leonhardt H* and Joffe B* (2013). LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation. Cell, 152, 584-598. (*communicating authors).

Spruijt CG, Gnerlich F, Smits AH, Pfaffeneder T, Jansen PW, Bauer C, Münzel M, Wagner M, Müller M, Khan F, Eberl HC, Mensinga A, Brinkman AB, Lephikov K, Müller U, Walter J, Boelens R, van Ingen H, Leonhardt H, Carell T and Vermeulen M (2013). Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives. Cell, 152, 1146-59.

Guizetti J, Schermelleh L, Mäntler J, Maar S, Poser I, Leonhardt H, Müller-Reichert T and Gerlich DW (2011). Cortical Constriction During Abscission Involves Helices Of ESCRT-III-Dependent Filaments. Science, 331, 1616-20.

Schermelleh L, Carlton PM, Haase S, Shao L, Winoto L, Kner P, Burke B, Cardoso MC, Agard DA, Gustafsson MGL, Leonhardt H* and Sedat JW* (2008). Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy. Science, 320, 1332-6. (*communicating authors).

Rothbauer U, Zolghadr K, Tillib S, Nowak D, Schermelleh L, Gahl A, Backmann N, Conrath K, Muyldermans S, Cardoso MC and Leonhardt H (2006). Targeting and tracing antigens in live cells with fluorescent nanobodies. Nature Methods, 3, 887-9.

Schermelleh L, Spada F, Easwaran HP, Zolghadr K, Margot JB, Cardoso MC and Leonhardt H (2005). Trapped in action: direct visualization of DNA methyltransferase activity in living cells. Nature Methods, 2, 751-756.

Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, Gray JW, Leonhardt H and Jaenisch R (2003). Induction of Tumors in Mice by Genomic Hypomethylation. Science, 300, 489-492.

Leonhardt H, Page AW, Weier HU and Bestor TH (1992). A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell, 71, 865-873.