SFB 1243 Cancer Evolution

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Bultmann, Sebastian

Dr. Sebastian Bultmann

LMU Biocenter, Human Biology and BioImaging


Ludwig-Maximilians-Universität München
Großhaderner Str. 2
82152 Planegg-Martinsried

Phone: +49 (0)89 2180 74233

Work group

Associate member (since Jan 2016)

10 Major publications related to project

Bultmann S, Stricker SH Entering the post-epigenomic age: back to epigenetics Open Biology (2018 Mar 28) 8: 180013. DOI: 10.1098/rsob.180013

Mulholland CB, Smets M, Schmidtmann E, Leidescher S, Markaki Y, Hofweber M, Qin W, Manzo M, Kremmer E, Thanisch K, Bauer C, Rombaut P, Herzog F, Leonhardt H and Bultmann S (2015). A modular open platform for systematic functional studies under physiological conditions. Nucleic Acids Res., 2015 May 24

Anton T, Bultmann S, Leonhardt H and Markaki Y (2014). Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system. Nucleus, 5, 163-172.

Bultmann S and Leonhardt H (2013). Fluorescence microscopy-based high-throughput screening for factors involved in gene silencing. Methods Mol Biol, 1042, 237-244.

Thanisch K, Schneider K, Morbitzer R, Solovei I, Lahaye T, Bultmann S* and Leonhardt H* (2013). Targeting and tracing of specific DNA sequences with dTALEs in living cells. Nucleic Acids Res., 42, e38. (*communicating authors)

Bultmann S*, Morbitzer R*, Schmidt CS, Thanisch K, Spada F, Elsaesser J, Lahaye T and Leonhardt H (2012). Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers. Nucleic Acids Res., 40, 5368-5377. (* first authors)

Schmidt CS, Bultmann S, Meilinger D, Zacher B, Tresch A, Maier KC, Peter C, Martin DE, Leonhardt H and Spada F (2012). Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state. PLoS One, 7, e52629.

Konstandin N*, Bultmann S*, Szwagierczak A, Dufour A, Ksienzyk B, Schneider F, Herold T, Mulaw M, Kakadia PM, Schneider S, Spiekermann K, Leonhardt H and Bohlander SK (2011). Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia. Leukemia, 25, 1649-1652. (*first authors)

Szwagierczak A, Brachmann A, Schmidt CS, Bultmann S, Leonhardt H and Spada F (2011). Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5-hydroxymethylcytosine. Nucleic Acids Res., 39, 5149-5156.

Szwagierczak A*, Bultmann S*, Schmidt CS, Spada F and Leonhardt H (2010). Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Res., 38. (*first authors)

Meilinger D, Fellinger K, Bultmann S, Rothbauer U, Bonapace IM, Klinkert WE, Spada F and Leonhardt H (2009). Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO Rep, 10, 1259-1264.