SFB 1243 Cancer Evolution
print


Breadcrumb Navigation


Content

SFB 1243 Publications

2018

Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V Binding of NUFIP2 to Rophin promotes recognition and regulation of ICOS mRNA. Nature Communications (2018) 9:299. DOI: 10.1038/s41467-017-02582-1.

2017

Essig K, Hu D, Guimaraes JC, Alterauge D, Edelmann S, Raj T, Kranich J, Behrens G, Helseke A, Floess S, Klein J, Maiser A, Marschall S, Hrabe de Angelis M, Leonhardt H, Calkhoven CF, Noessner E, Brocker T, Huehn J, Krug AB,  Zavolan M, Baumjohann D, Heissmeyer V Roquin suppresses the PI3K-mTOR Signaling Pathway to inhibit T helper cell differentiation and conversion of Treg to Tfr cellsImmunity 47, 1067-1082 (2017 Dec 19) https://doi.org/10.1016/j.immuni.2017.11.008

Mottok A, Jurinovic V, Farinha P, Rosenwald A, Leich E, Ott G, Horn H, Klapper W, Boesl M, Hiddemann W, Steidl C, Connors JM, Sehn LH, Gascoyne RD, Hoster E, Weigert O, Kridel R FOXP1 expression is a prognostic biomarker in follicular lymphoma treated with Rituximab-containing regimens. Blood (2017, accepted Oct 27; Epub ahead of print)

Garz AK, Wolf S, Grath S, Gaidzik V, Habringer S, Vick B, Rudelius M, Ziegenhain C, Herold S, Weickert M, Smets M, Peschel C, Oostendorp R, Bultmann S, Jeremias I, Thiede C, Döhner K, Keller U, Götze K Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in FLT3-ITD AML with concurrent epigenetic mutations. Oncotarget (2017 Oct 16). Online ISSN: 1949-2553.
https://doi.org/10.18632/oncotarget.21877

Weigert O, Weinstock DM The promises and challenes of using gene mutations for patient stratification in follicular lympohma. Blood (2017 Sept 28) 130(13): 1491-1498.

Reiter K, Polzer H, Krupka C, Maiser A, Vick B, Rothenberg-Thurley M, Metzeler KH, Dörfel D, Salih HR, Jung G, Nößner E, Jeremias I, Hiddemann W, Leonhardt H, Spiekermann K, Subklewe M, Greif PA Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia. Leukemia (2017 Aug 14). doi: 10.1038/leu.2017.257. [Epub ahead of print]
http://www.nature.com/leu/journal/vaop/ncurrent/full/leu2017257a.html?foxtrotcallback=true

Vieth B, Ziegenhain C, Parekh S, Enard W, Hellmann I. powsimR: Power analysis for bulk and single cell RNA-seq experiments. Bioinformatics (2017). https://doi.org/10.1093/bioinformatics/btx435

Krautenbacher N, Theis F, Fuchs C Correcting classifiers for sample selection bias in two-phase case-control studies.
Computational and Mathematical Methods in Medicine (2017) Article ID 7847531. DOI:10.1155/2017/7847531

Schlenker R, Olguín-Contreras LF, Leisegang M, Schnappinger J, Disovic A, Rühland S, Nelson PJ, Leonhardt H, Harz H, Wilde S, Schendel DJ, Uckert W, Willimsky G, Noessner E. Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy. Cancer Research (2017) 11(13): 3577-3590. DOI: 10.1158/0008-5472.CAN-16-1922

Ziegenhain C, Vieth B, Parekh S, Reinius B, Guillaumet-Adkins A, Smets M, Leonhardt H, Heyn H, Hellmann I, Enard W.  Comparative Analysis of Single-Cell RNA Sequencing Methods. Molecular Cell (2017) 65: 631-643. http://dx.doi.org/10.1016/j.molcel.2017.01.023

Seyednasrollah F, Koestler D, Wang T, Piccolo S, Vega R, Greiner R, Fuchs C, ..., Costello J, Prostate Cancer DREAM Challenge Community A DREAM challenge to build prediction models for short-term discontinuation of docetaxel in metastatic castration-resistant prostate cancer. Journal of Clinical Oncology Clinical Cancer Informatics (2017)

Guinney J, Wang T, Laajala T, Fuchs C, ..., Costello J, Prostate Cancer Challenge DREAM Community Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data. The Lancet Oncology (2017):18, 132-142. DOI: 10.1016/S1470-2045(16)30560-5

Jacobsen C, Kopp N, Layer JV, Redd RA, Tschuri S, Haebe S, van BodegomD, Bird L, Christie AL, Christodoulou A, Saur A, Tivey T, Zapf S, Deepak B, Zimber-Strobl U, Rodig SJ, Weigert O, Weinstock DM.  HSP90 inhibition overcomes ibrutinib resistance in mantel cell lymphoma. Blood (2017) 128 (21): 2517-2526. DOI 10.1182/blood-2016-04-711176

Buggenthin F, Buettner F, Hoppe PS, Endele M, Kroiss, M, Strasser, M, Schwarzfischer M, Loeffler D, Kookaliaris KD, Hilsenbeck O, Schroeder T, Theis FJ, Marr C. Prospective identification of hematopoietic lineage choice by deep learning. Nature Methods (2017) 14: 403-406. doi:10.1038/nmeth.4182

2016

Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, Görlich D, Büchner T, Hiddemann W, Berdel WE, Wörmann B, Cheok M, Preudhomme C, Dombret H, Metzeler K, Buske C, Löwenberg B, Valk PJ, Zandstra PW, Minden MD, Dick JE, Wang JC. A 17-gene stemness score for rapid determination of risk in acute leukaemia. Nature. (2016)  Dec 15;540(7633):433-437. doi: 10.1038/nature20598. Epub 2016 Dec 7. PubMed PMID: 27926740

Riba J, Renz N, Niemöller C, Bleul S, Pfeifer D, Stosch JM, Metzeler KH, Hackanson B, Lübbert M, Duyster J, Koltay P, Zengerle R, Claus R, Zimmermann S, Becker H. Molecular Genetic Characterization of Individual Cancer Cells Isolated via Single-Cell Printing. PLoS One. (2016) Sep 22;11(9):e0163455. doi: 10.1371/journal.pone.0163455. eCollection 2016. PubMed PMID: 27658049; PubMed Central PMCID: PMC5033393.

Diesch J, Zwick A, Garz AK, Palau A, Buschbeck, Götze K A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers. Clinical Epigenetics (2016) Jun 21; 8:71. doi: 10.1186/s13148-016-0237-y

Ponce LP, Fenn NC, Mortiz N, Krupka C, Kozik JH, Lauber K, Sublewe M, Hopfner KPSIRTα-antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells. Oncotarget, Advance Publications (2016) 1-18. www.impactjournals.com/oncotarget

Ebinger S, Özdemir EZ, Ziegenhain C, Tiedt S, Castro Alves C, Grunert M, Dworzak M, Lutz C, Turati VA, Enver T, Horny HP, Sotlar K, Parekh S, Spiekermann K, Hiddemann W, Schepers A, Polzer B, Kirsch S, Hoffmann M, Knapp B, Hasenauer J, Pfeifer H, Panzer-Grümayer R, Enard W, Gires O, Jeremias I. Characterization of Rare, Dormant and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia. Cancer Cell (2016) 30: 849-862. http://dx.doi.org/10.1016/j.ccell.2016.11.002

Kondofersky I, Laimighofer M, Kurz C, Krautenbacher N, Söllner J, Dargatz P, Scherb H, Ankerst D, Fuchs C Three general concepts to improve risk prediction: good data, wisdom of the crowd, recalibration. F1000Research (2016):5(2671). DOI: 10.12688/f1000research.8680.1.

Jurinovic v, Kridel R, Staiger AM, Szczepanowski M, Horn H, Dreyling MH, Rosenwald A, Ott G, Klapper W, Zelenetz AD, Barr PM, Friedberg JW, Ansell S, Sehn LH, Connors JM, Gascoyne RD, Hiddemann W, Unterhalt M, Wenstock DM, Weigert O. Clinicogenetic risk models predict early progression of follicular lymphoma after first-line immunochemotherapy. Blood (2016) 128(8): 1112-1120. doi:10.1182/blood-2016-05-717355

Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Harmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K, on behalf of the AMLCG Study Group. Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia. Blood (2016) 128(5): 686-698. DOI 10.1182/blood-2016-01- 693879

Parekh S, Ziegenhain C, Vieth B, Enard W, Hellmann I. The impact of amplification on differential expression analyses by RNA-seq. Nature Scientific Reports (2016) 6:25533. DOI: 10.1038/srep25533 www.nature.com/scientificreports/

Kondofersky I, Theis F, Fuchs C Inferring catalysis in biological systems. IET Systems Biology (2016):10,210-218. DOI: 10.1049/iet-syb.2015.0087.

Melchardt T, Hufnagl C, Weinstock DM, Kopp N, Neureiter D, Tränkenschuh W, Hackl H, Weiss L, Rinnerthaler G, Hartmann TN, Greil R, Weigert O, Egle A. Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones. Oncotarget, Advanced Publications.  (2016) www.impactjournals.com/oncotarget

Hartmann L, Dutta S, Opatz S, Vosberg S, Reiter K, Leubolt G, Metzeler KH, Herold, T, Bamopoulos SA, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Hopfner KP, Graf A, Krebs S, Blum H, Middeke JM, Stölzel F, Thiede C, Wolf S, Bohlander SK, Preiss C, Chen-Wichmann L, Wichmann C, Sauerland MC, Büchner T, Berdel WE, Wörmann BJ, Braess J, Hiddemann W, Spiekermann K, Greif PA. ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation. Nature Communications (2016) 7:11733. doi: 10.1038/ncomms11733.