SFB 1243 Cancer Evolution
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SFB 1243 Publications

2017

Reiter K, Polzer H, Krupka C, Maiser A, Vick B, Rothenberg-Thurley M, Metzeler KH, Dörfel D, Salih HR, Jung G, Nößner E, Jeremias I, Hiddemann W, Leonhardt H, Spiekermann K, Subklewe M, Greif PA Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia. Leukemia (2017) 1-10.

Vieth B, Ziegenhain C, Parekh S, Enard W, Hellmann I. powsimR: Power analysis for bulk and single cell RNA-seq experiments. Bioinformatics (2017). https://doi.org/10.1093/bioinformatics/btx435

Schlenker R, Olguín-Contreras LF, Leisegang M, Schnappinger J, Disovic A, Rühland S, Nelson PJ, Leonhardt H, Harz H, Wilde S, Schendel DJ, Uckert W, Willimsky G, Noessner E. Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy. Cancer Research (2017) 11(13): 3577-3590. DOI: 10.1158/0008-5472.CAN-16-1922

Ziegenhain C, Vieth B, Parekh S, Reinius B, Guillaumet-Adkins A, Smets M, Leonhardt H, Heyn H, Hellmann I, Enard W.  Comparative Analysis of Single-Cell RNA Sequencing Methods. Molecular Cell (2017) 65: 631-643. http://dx.doi.org/10.1016/j.molcel.2017.01.023

Jacobsen C, Kopp N, Layer JV, Redd RA, Tschuri S, Haebe S, van BodegomD, Bird L, Christie AL, Christodoulou A, Saur A, Tivey T, Zapf S, Deepak B, Zimber-Strobl U, Rodig SJ, Weigert O, Weinstock DM.  HSP90 inhibition overcomes ibrutinib resistance in mantel cell lymphoma. Blood (2017) 128 (21): 2517-2526. DOI 10.1182/blood-2016-04-711176

Buggenthin F, Buettner F, Hoppe PS, Endele M, Kroiss, M, Strasser, M, Schwarzfischer M, Loeffler D, Kookaliaris KD, Hilsenbeck O, Schroeder T, Theis FJ, Marr C. Prospective identification of hematopoietic lineage choice by deep learning. Nature Methods (2017) 14: 403-406. doi:10.1038/nmeth.4182

2016

Ponce LP, Fenn NC, Mortiz N, Krupka C, Kozik JH, Lauber K, Sublewe M, Hopfner KPSIRTα-antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells. Oncotarget, Advance Publications (2016) 1-18. www.impactjournals.com/oncotarget

Ebinger S, Özdemir EZ, Ziegenhain C, Tiedt S, Castro Alves C, Grunert M, Dworzak M, Lutz C, Turati VA, Enver T, Horny HP, Sotlar K, Parekh S, Spiekermann K, Hiddemann W, Schepers A, Polzer B, Kirsch S, Hoffmann M, Knapp B, Hasenauer J, Pfeifer H, Panzer-Grümayer R, Enard W, Gires O, Jeremias I. Characterization of Rare, Dormant and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia. Cancer Cell (2016) 30: 849-862. http://dx.doi.org/10.1016/j.ccell.2016.11.002

Jurinovic v, Kridel R, Staiger AM, Szczepanowski M, Horn H, Dreyling MH, Rosenwald A, Ott G, Klapper W, Zelenetz AD, Barr PM, Friedberg JW, Ansell S, Sehn LH, Connors JM, Gascoyne RD, Hiddemann W, Unterhalt M, Wenstock DM, Weigert O. Clinicogenetic risk models predict early progression of follicular lymphoma after first-line immunochemotherapy. Blood (2016) 128(8): 1112-1120. doi:10.1182/blood-2016-05-717355

Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Harmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K, on behalf of the AMLCG Study Group. Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia. Blood (2016) 128(5): 686-698. DOI 10.1182/blood-2016-01- 693879

Parekh S, Ziegenhain C, Vieth B, Enard W, Hellmann I. The impact of amplification on differential expression analyses by RNA-seq. Nature Scientific Reports (2016) 6:25533. DOI: 10.1038/srep25533 www.nature.com/scientificreports/

Melchardt T, Hufnagl C, Weinstock DM, Kopp N, Neureiter D, Tränkenschuh W, Hackl H, Weiss L, Rinnerthaler G, Hartmann TN, Greil R, Weigert O, Egle A. Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones. Oncotarget, Advanced Publications.  (2016) www.impactjournals.com/oncotarget

Hartmann L, Dutta S, Opatz S, Vosberg S, Reiter K, Leubolt G, Metzeler KH, Herold, T, Bamopoulos SA, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Hopfner KP, Graf A, Krebs S, Blum H, Middeke JM, Stölzel F, Thiede C, Wolf S, Bohlander SK, Preiss C, Chen-Wichmann L, Wichmann C, Sauerland MC, Büchner T, Berdel WE, Wörmann BJ, Braess J, Hiddemann W, Spiekermann K, Greif PA. ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation. Nature Communications (2016) 7:11733. doi: 10.1038/ncomms11733.