SFB 1243 Cancer Evolution

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Zimber-Strobl, Ursula

PD Dr. Ursula Zimber-Strobl

Helmholtz Zentrum München, Research Unit Gene Vectors, Großhadern


Helmholtz Zentrum München
Research Unit Gene Vectors
Marchioninistr. 25
81377 München

Phone: +49 (0)89 3187-1523

Website: Research Group B Cell Development and Activation

Work group

A13 Genetic evolution of pre-germinal center B cell lymphomas in transgenic mice with the focus on Mantle Cell Lymphoma

10 Major publications related to project

Frankenberger S, Davari K, Fischer-Burkart S, Bottcher K, Tomi NS, Zimber-Strobl U and Jungnickel B (2014). Checkpoint kinase 1 negatively regulates somatic hypermutation. Nucleic Acids Res., 42, 3666-3674.

Hojer C, Frankenberger S, Strobl LJ, Feicht S, Djermanovic K, Jagdhuber F, Hömig-Hölzel C, Ferch U, Ruland J, Rajewsky K and Zimber-Strobl U (2014). B-cell expansion and lymphomagenesis induced by chronic CD40 signaling is strictly dependent on CD19. Cancer Res., 74, 4318-28.

Hampel F, Ehrenberg S, Hojer C, Draeseke A, Marschall-Schröter G, Kühn R, Mack B, Gires O, Vahl CJ, Schmidt-Supprian M, Strobl LJ and Zimber-Strobl U (2011). CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling. Blood, 118, 6321-6331.

Luckerath K, Kirkin V, Melzer IM, Thalheimer FB, Siele D, Milani W, Adler T, Aguilar-Pimentel A, Horsch M, Michel G, Beckers J, Busch DH, Ollert M, Gailus-Durner V, Fuchs H, Hrabĕ de Angelis M, Staal FJ, Rajalingam K, Hueber AO, Strobl LJ, Zimber-Strobl U and Zörnig M (2011). Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain. Blood, 117, 519-529.

Turchinovich G, Vu TT, Frommer F, Kranich J, Schmid S, Alles M, Loubert JB, Goulet JP, Zimber-Strobl U, Schneider P, Bachl J, Pearson R, Crossley M, Agenès F and Kirberg J (2011). Programming of marginal zone B-cell fate by basic Kruppel-like factor (BKLF/KLF3). Blood 117, 3780-379

Pechloff K, Holch J, Ferch U, Schweneker M, Brunner K, Kremer M, Sparwasser T, Quintanilla-Martinez L, Zimber-Strobl U, Streubel B, Gewies A, Peschel C and Ruland R (2010). The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med, 207, 1031-1044.

Kohlhof H, Hampel F, Hoffmann R, Burtscher H, Weidle U, Eick D, Zimber-Strobl U* and Strobl LJ* (2009). Notch1, Notch2 and EBNA2 signaling differently affect proliferation and survival of EBV-infected B cells. Blood, 113, 5506-15.*equivalent authors

Hömig-Hölzel C, Hojer C, Rastelli J, Casola S, Strobl LJ, Müller W, Quintanilla-Martinez L, Gewies A, Ruland J, Rajewsky K and Zimber-Strobl U (2008). Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis. J Exp Med., 205, 1317-29.

Rastelli J, Hömig-Hölzel C, Seagal J, Müller W, Hermann AC, Rajewsky K and Zimber-Strobl U (2008). LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1. Blood, 111, 1448-55.

Besseyrias V*, Fiorini E*, Strobl LJ*, Zimber-Strobl U*, Dumortier A, Koch U, Arcangeli ML, Ezine S, Macdonald HR and Radtke F (2007). Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J Exp Med., 204, 331-43. *equivalent first author