SFB 1243 Cancer Evolution
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Rad, Roland

Prof. Dr. Roland Rad

Klinikum rechts der Isar, II. Medizinische Klinik, Technische Universität München

Contact

Klinikum rechts der Isar
II. Medizinische Klinik
Technische Universität München
Ismaninger Str. 22
81675 München

Phone: +49 (0)89 4140-4374

Website: Klinikum rechts der Isar: Gastroenterology

Work group

A13 Genetic evolution of pre-germinal center B cell lymphomas in transgenic mice with the focus on Mantle Cell Lymphoma

10 Major publications related to project

Rad R*, Rad L, Wang W, Strong A, Ponstingl H, Bronner I, Mayho M, Steiger K, Weber J, Hieber M, Veltkamp C, Eser S, Geumann U, Öllinger R, Zukowska M, Barenboim M, Cadiñanos J, Friedrich M, Varela I, Constantino-Casas F, Sarver A, ten Hoeve J, Prosser H, Seidler B, Bauer J, Heikenwälder M, Metzakopian E, Krug A, Ehmer U, Schneider G, Knösel T, Rümmele P, Aust D, Grützmann R, Pilarsky C, Ning Z, Wessels L, Schmid RM, Quail MA, Vassilliou GS, Esposito I, Liu P, Saur D and Bradley A (2015). A conditional PiggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer. Nature Genetics, 47, 47-56. *corresponding author

Baumann U, Fernández-Sáiz V, Rudelius M, Lemeer S, Rad R, Knorn A, Slawska J, Engel K, Jeremias I, Li Z, Tomiatti V, Illert A, Targosz B, Braun M, Perner S, Leitges M, Klapper W, Dreyling M, Miething C, Lenz G, Rosenwald A, Peschel C, Keller U, Kuster B and Bassermann F (2014). Disruptions of the PRKCD-Fbxo25-Hax-1 axis attenuate the apoptotic response and drive lymphomagenesis. Nature Medicine, 20, 1401-9.

Schönhuber N, Seidler B, Schuck K, Veltkamp C, Schachtler C, Zukowska M, Eser S, Feyerabend TB, Paul MC, Eser P, Klein S, Lowy AM, Banerjee R, Yang F, Lee CL, Moding EJ, Kirsch DG, Scheideler A, Alessi DR, Varela I, Bradley A, Kind A, Schnieke AE, Rodewald HR, Rad R, Schmid RM, Schneider G and Saur D (2014). A next-generation dual-recombination system for sequential time and host specific genetic manipulation of pancreatic cancer. Nature Medicine, 20, 1340-7.

Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber M, Arbeiter A, Klein S, Kong B, Michalski CW, Schlitter AM, Esposito I, Kind AJ, Rad L, Schnieke AE, Baccarini M, Alessi DR, Rad R, Schmid RM, Schneider G and Saur D (2013). Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. Cancer Cell, 23, 406-20.

Rad R*, Cadiñanos J, Rad L, Varela I, Strong A, Kriegl L, Constantino-Casas F, Eser S, Hieber M, Seidler B, Price S, Fraga MF, Calvanese V, Hoffman G, Ponstingl H, Schneider G, Yusa K, Grove C, Schmid RM, Wang W, Vassiliou G, Kirchner T, McDermott U, Liu P, Saur D and Bradley A (2013). A genetic progression model of BrafV600E-induced intestinal tumorigenesis reveals targets for therapeutic intervention. Cancer Cell, 24, 15-29. *corresponding author

Stephens PJ, Tarpey PS, Davies H, Van Loo P, Greenman C, Wedge DC, Nik-Zainal S, Martin S, Varela I, Bignell GR, Yates LR, Papaemmanuil E, Beare D, Butler A, Cheverton A, Gamble J, Hinton J, Jia M, Jayakumar A, Jones D, Latimer C, Lau KW, McLaren S, McBride DJ, Menzies A, Mudie L, Raine K, Rad R, Chapman MS, Teague J, Easton D, Langerød A; Oslo Breast Cancer Consortium (OSBREAC), Lee MT, Shen CY, Tee BT, Huimin BW, Broeks A, Vargas AC, Turashvili G, Martens J, Fatima A, Miron P, Chin SF, Thomas G, Boyault S, Mariani O, Lakhani SR, van de Vijver M, van 't Veer L, Foekens J, Desmedt C, Sotiriou C, Tutt A, Caldas C, Reis-Filho JS, Aparicio SA, Salomon AV, Børresen-Dale AL, Richardson AL, Campbell PJ, Futreal PA and Stratton MR (2012). The landscape of cancer genes and mutational processes in breast cancer. Nature, 486, 400-4.

Vassiliou G, Cooper J, Rad R, Li J, Rice S, Uren A, Rad L, Ellis P, Andrews R, Banerjee R, Wright P, Arends M and Bradley A (2011). Mutant nucleophosmin and cooperating pathways drive leukaemia initiation and progression in mice. Nature Genetics, 43, 470-5.

Rad R, Rad L, Wang W, Cadinanos J, Vassiliou G, Rice S, Campos LS, Yusa K, Banerjee R, Li MA, Strong A, Lu D, Ellis P, Conte N, Yang FT, Liu P and Bradley A (2010). PiggyBac Transposon mutagenesis: A Tool for Cancer Gene Discovery in Mice. Science, 330, 1104-7.

Rad R, Ballhorn W, Voland P, Brenner L, Mages J, Lang R, Schmid RM, Bauer S, Prinz C and Krug A (2009). Extra- and intracellular pathogen recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology, 136, 2247-57.

Yusa K, Rad R, Takeda J and Bradley A (2009). Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nature Methods, 6, 363-9.