SFB 1243 Cancer Evolution

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Oostendorp, Robert

Prof. Dr. Robert Oostendorp

Klinikum rechts der Isar, III. Medizinische Klinik, Technische Universität München


Klinikum rechts der Isar
III. Medizinische Klinik
Technische Universität München
Ismaninger Str. 22
81675 München

Phone: +49 (0)89 4140-6056

Website: Klinikum rechts der Isar: Haematology/Oncology
Website: A09 doctoral Position description (pdf)

Work group

A09 Dissecting the clonal hierarchy in MDS and involvement of the niche in the transition to secondary AML

10 Major publications related to project

Tomiatti V, Istvanffy R, Pietschmann E, Kratzat S, Hoellein A, Quintinilla-Fend L, von Bubnoff N, Peschel C, Oostendorp RAJ* and Keller U* (2014). Cks1 is a critical regulator of hematopoietic stem cell quiescence and cell cycling, operating upstream of Cdk inhibitors. Oncogene, 2014 Nov 24;0. *co-Senior authors

Wöhrer S, Knapp DJ, Copley MR, Benz C, Kent DG, Rowe K, Babovic S, Mader H, Oostendorp RAJ and Eaves CJ (2014). Distinct Stromal Cell Factor Combinations Can Separately Control Hematopoietic Stem Cell Survival, Proliferation, and Self-Renewal. Cell Rep., 7, 1956-67.

Florian MC, Kalpana J. Nattamai KJ, Dörr K, Marka G, Überle B, Vas V, Eckl C, Andrä I, Schiemann M, Oostendorp RAJ, Scharffetter-Kochanek K, Kestler HA, Zheng Y and Geiger H (2013). A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature, 503, 392-396.

Lutzny G, Kocher T, Schmidt-Supprian M, Rudelius M, Klein-Hitpass R, Finch AJ, Dürig J, Wagner M, Haferlach C, Kohlmann A, Schnittger S, Seifert M, Wanninger S, Zaborsky N, Oostendorp R, Ruland J, Leitges M, Kuhnt T, Schäfer Y, Lampl B, Peschel C, Egle A and Ringshausen I (2013). Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo. Cancer Cell, 23, 77-92.

Istvanffy R, Kröger M, Eckl C, Gitzelmann S, Vilne B, Bock F, Graf S, Schiemann M, Keller, UB, Peschel C and Oostendorp RAJ (2011). Stromal pleiotrophin regulates repopulation behavior of hematopoetic stem cells. Blood, 118, 2712-22.

Parmar A, Marz S, Rushton S, Holzwarth C, Lind K, Kayser S, Döhner K, Peschel C, Oostendorp RAJ and Götze KS (2011). Stromal niche cells protect early leukemic FLT3-ITD+ progenitor cells against first-generation FLT3 tyrosine kinase inhibitors. Cancer Res., 71, 4696-706.

Renström J, Istvanffy R, Gauthier K, Shimino A, Mages J, Jardon-Alvarez A, Kröger M, Schiemann M, Busch DH, Esposito I, Lang R, Peschel C and Oostendorp RAJ (2009). Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells. Cell Stem Cell, 5, 157-167.

Ledran MH, Krassowska A, Armstrong L, Dimmick I, Renström J, Lang R, Yung S, Santibanez-Coref M, Dzierzak E, Stojkovic M, Oostendorp RAJ, Forrester L and Lako M (2008). Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Cell Stem Cell, 3, 85-98.

Oostendorp RAJ, Gilfillan S, Parmar A, Schiemann M, Marz S, Niemeyer M, Schill S, Hammerschmid E, Jacobs VR, Peschel C and Götze KS (2008). Oncostatin M-mediated regulation of KIT-ligand-induced extracellular signal-regulated kinase signaling maintains hematopoietic repopulating activity of Lin-CD34+CD133+ cord blood cells. Stem Cells, 26, 2164-72.

Oostendorp RAJ, Harvey KN, Kusadasi N, de Bruijn MFTR, Saris C, Ploemacher RE, Medvinsky AL and Dzierzak EA (2002). Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity. Blood, 99, 1183-9.