SFB 1243 Cancer Evolution
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Götze, Katharina

Prof. Dr. Katharina Götze

Klinikum rechts der Isar, III. Medizinische Klinik, Technische Universität München

Contact

Klinikum rechts der Isar
III. Medizinische Klinik
Technische Universität München
Ismaninger Str. 22
81675 München

Phone: +49 (0)89 4140-5618

Website: Klinikum rechts der Isar: Haematology/Oncology
Website: A09 doctoral Position description (pdf)

Work group

A09 Dissecting the clonal hierarchy in MDS and involvement of the niche in the transition to secondary AML

10 Major publications related to project

Jilg S, Reidel V, Müller-Thomas C, König J, Schauwecker J, Höckendorf U, Huberle C, Gorka O, Schmidt B, Burgkart R, Ruland J, Kolb HJ, Peschel C, Oostendorp RAJ, Götze K and Jost P (2015). Blockade of BCL-2 proteins efficiently induces apoptosis in progenitor cells of high-risk Myelodysplastic Syndromes (MDS) patients. Leukemia, 2015 Jul 8. [Epub ahead of print]

Braulke F, Platzbecker U, Müller-Thomas C, Götze K, Germing U, Brümmendorf TH, Nolte F, Hofmann WK, Giagounidis AA, Lübbert M, Greenberg PL, Bennett JM, Sole' F, Mallo M, Slovak ML, Ohyashiki K, Le Beau MM, Tüchler H, Pfeilstöcker M, Nösslinger T, Hildebrandt B, Shirneshan K, Aul C, Stauder R, Sperr WR, Valent P, Fonatsch C, Trümper L, Haase D and Schanz J (2015). Validation of cytogenetic risk groups according to International Prognostic Scoring Systems by peripheral blood CD34+FISH: results from a German diagnostic study in comparison with an international control group. Haematologica, 100, 205-13.

Philipp-Abbrederis K, Herrmann K, Knop S, Schottelius M, Eiber M, Lückerath K, Pietschmann E, Habringer S, Gerngroß C, Franke K, Rudelius M, Schirbel A, Lapa C, Schwamborn K, Steidle S, Hartmann E, Rosenwald A, Kropf S, Beer AJ, Peschel C, Einsele H, Buck AK, Schwaiger M, Götze K, Wester HJ and Keller U (2015). In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma. EMBO Mol Med., 7, 477-87.

Dechow T*, Steidle S*, Götze KS*, Rudelius M, Behnke K, Pechloff K, Kratzat S, Bullinger L, Fend F, Soberon V, Mitova N, Li Z, Thaler M, Bauer J, Pietschmann E, Albers C, Grundler R, Schmidt-Supprian M, Ruland J, Peschel C, Duyster J, Rose-John S, Bassermann F and Keller U (2014). GP130 activation induces myeloma and collaborates with MYC. J Clin Invest, 124, 5263-74. * equal contribution

Müller-Thomas C, Rudelius M, Rondak IC, Haferlach T, Schanz J, Huberle C, Schmidt B, Blaser R, Kremer M, Peschel C, Germing U, Platzbecker U and Götze K (2014). Response to azacitidine is independent of p53 expression in higher-risk myelodysplastic syndromes and secondary acute myeloid leukemia. Haematologica, 99, 179-81.

Platzbecker U, Braulke F, Kündgen A, Götze K, Bug G, Schönefeldt C, Shirneshan K, Röllig C, Bornhäuser M, Naumann R, Neesen J, Giagounidis A, Hofmann WK, Ehninger G, Germing U, Haase D and Wermke M (2013). Sequential combination of azacitidine and lenalidomide in del(5q) higher-risk myelodysplastic syndromes or acute myeloid leukemia: a phase I study. Leukemia, 27, 1403-7.

Leischner H, Albers C, Grundler R, Razumovskaya E, Spiekermann K, Bohlander S, Rönnstrand L, Götze K, Peschel C and Duyster J (2012). SRC is a signaling mediator in FLT3-ITD but not in FLT3-TKD positive AML. Blood, 119, 4026-33.

Parmar A, Marz S, Rushton S, Holzwarth C, Lind K, Kayser S, Döhner K, Peschel C, Oostendorp RAJ and Götze KS (2011). Stromal niche cells protect early leukemic FLT3-ITD+ progenitor cells against first-generation FLT3 tyrosine kinase inhibitors. Cancer Res, 71, 4696-706.

Oostendorp RA, Gilfillan S, Parmar A, Schiemann M, Marz S, Niemeyer M, Schill S, Hammerschmid E, Jacobs VR, Peschel C and Götze KS (2008). Oncostatin M-mediated regulation of KIT-ligand-induced extracellular signal-regulated kinase signaling maintains hematopoietic repopulating activity of Lin-CD34+CD133+ cord blood cells. Stem Cells, 26, 2164-72.

Götze KS, Schiemann M, Marz S, Jacobs VR, Debus G, Peschel C and Oostendorp RA (2007). CD133-enriched CD34(-) (CD33/CD38/CD71)(-) cord blood cells acquire CD34 prior to cell division and hematopoietic activity is exclusively associated with CD34 expression. Exp Hematol., 35, 1408-14.