SFB 1243 Cancer Evolution
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Bassermann, Florian

Prof. Dr. Florian Bassermann

Klinikum rechts der Isar, III. Medizinische Klinik, Technische Universität München

Contact

Klinikum rechts der Isar
III. Medizinische Klinik
Technische Universität München
Ismaninger Str. 22
81675 München

Phone: +49 (0)89 4140-5038

Website: Website Florian Bassermann

Work group

A04 Dissecting aberrant functions of the ubiquitin proteasome system in the treatment-induced evolution of Mantle Cell Lymphoma

10 Major publications related to project

Bassermann F, Eichner R and Pagano M (2014). The ubiquitin proteasome system – Implications for cell cycle control and the targeted treatment of cancer. BBA-Mol Cell Res, 184, 150-62.

Baumann U, Fernandez-Saiz V, Rudelius M, Lemeer S, Rad R, Knorn AM, Slawska J, Engel K, Jeremias I, Li Z, Tomiatti V, Illert AL, Targosz BS, Braun M, Perner S, Leitges M, Klapper W, Dreyling M, Miething C, Lenz G, Rosenwald A, Peschel C, Keller U, Kuster B and Bassermann F (2014). Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis. Nature Medicine, 20, 1401-1409.

Dechow T, Steidle S, Götze K, Rudelius M, Behnke K, Pechloff K, Kratzat S, Bullinger L, Fend F, Soberon V, Mitova N, Li Z, Thaler M, Bauer J, Pietschmann E, Albers C, Grundler R, Schmidt-Supprian M, Ruland J, Peschel C, Duyster J, Rose-John S, Bassermann F and Keller U (2014). gp130 activation induces myeloma and collaborates with Myc. J Clin Invest, 124, 5263-5274.

Fernández-Sáiz V, Targosz BS, Lemeer S, Eichner R, Langer C, Bullinger L, Reiter C, Slotta Huspenina J, Schroeder S, Knorn A, Kurutz J, Peschel C, Pagano M, Kuster B and Bassermann F (2013). SCF-Fbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. Nature Cell Biol, 15, 72-81.

Hoellein A, Graf S, Bassermann F, Schoeffmann S, Platz U, Holzlwimmer G, Kroger M, Peschel C, Oostendorp R, Quintanilla-Fend L and Keller U (2012). Cks1 Promotion of S Phase Entry and Proliferation Is Independent of p27Kip1 Suppression. Mol Cell Biol, 32, 2416-2427.

Dehan E, Bassermann F, Guardavaccaro D, Vasiliver-Shamis G, Cohen M, Lowes KN, Dustin M, Huang DC, Taunton J and Pagano M (2009). betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol Cell, 33, 109-116.

Bassermann F, Frescas D, Guardavaccaro D, Busino L, Peschiaroli A and Pagano M (2008). The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell, 134, 256-267.

Busino L, Bassermann F, Maiolica A, Lee C, Nolan PM, Godinho SI, Draetta GF and Pagano M (2007). SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science, 316, 900-904.

Frescas D, Guardavaccaro D, Bassermann F, Koyama-Nasu R and Pagano M (2007). The histone demethylase JHDM1B is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature, 450, 309-313.

Bassermann F, von Klitzing C, Munch S, Bai RY, Kawaguchi H, Morris SW, Peschel C and Duyster J (2005). NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry. Cell, 122, 45-57.