SFB 1243 Cancer Evolution

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Bultmann, Sebastian

Dr. Sebastian Bultmann

LMU Biocenter, Human Biology and BioImaging


Ludwig-Maximilians-Universität München
Großhaderner Str. 2
82152 Planegg-Martinsried

Phone: +49 (0)89 2180 74233

Work group

Associate member (since Jan 2016)

10 Major publications related to project

Mulholland CB, Smets M, Schmidtmann E, Leidescher S, Markaki Y, Hofweber M, Qin W, Manzo M, Kremmer E, Thanisch K, Bauer C, Rombaut P, Herzog F, Leonhardt H and Bultmann S (2015). A modular open platform for systematic functional studies under physiological conditions. Nucleic Acids Res., 2015 May 24

Anton T, Bultmann S, Leonhardt H and Markaki Y (2014). Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system. Nucleus, 5, 163-172.

Bultmann S and Leonhardt H (2013). Fluorescence microscopy-based high-throughput screening for factors involved in gene silencing. Methods Mol Biol, 1042, 237-244.

Thanisch K, Schneider K, Morbitzer R, Solovei I, Lahaye T, Bultmann S* and Leonhardt H* (2013). Targeting and tracing of specific DNA sequences with dTALEs in living cells. Nucleic Acids Res., 42, e38. (*communicating authors)

Bultmann S*, Morbitzer R*, Schmidt CS, Thanisch K, Spada F, Elsaesser J, Lahaye T and Leonhardt H (2012). Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers. Nucleic Acids Res., 40, 5368-5377. (* first authors)

Schmidt CS, Bultmann S, Meilinger D, Zacher B, Tresch A, Maier KC, Peter C, Martin DE, Leonhardt H and Spada F (2012). Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state. PLoS One, 7, e52629.

Konstandin N*, Bultmann S*, Szwagierczak A, Dufour A, Ksienzyk B, Schneider F, Herold T, Mulaw M, Kakadia PM, Schneider S, Spiekermann K, Leonhardt H and Bohlander SK (2011). Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia. Leukemia, 25, 1649-1652. (*first authors)

Szwagierczak A, Brachmann A, Schmidt CS, Bultmann S, Leonhardt H and Spada F (2011). Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5-hydroxymethylcytosine. Nucleic Acids Res., 39, 5149-5156.

Szwagierczak A*, Bultmann S*, Schmidt CS, Spada F and Leonhardt H (2010). Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Res., 38. (*first authors)

Meilinger D, Fellinger K, Bultmann S, Rothbauer U, Bonapace IM, Klinkert WE, Spada F and Leonhardt H (2009). Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO Rep, 10, 1259-1264.